Toxicity Studies on Selenium Disulfide Suspension*

Experimental studies on carbon disulfide poisoning.

Selenium Deficiency and Toxicity in the Environment

Selenium safeguards the liver against 5flurouracil-induced toxicity

Hepatotoxic effect of 5-Fluourouracil (5-FU) can deprive cancer patients of maximum therapeutic benefits. Aim: This study assessed the ability of selenium (Se) to protect against hepatotoxicity induced by 5-FU in rats. Forty adult albino rats were groups and used. Rats in group A (control) were treated intraperitoneally (ip) with 0.2ml of normal saline daily for 5 days. Rats in groups B1-B3 wer...

Studies on the Disulfide Bonds of Glycoprotein Hormones

The first disulfide to be reduced in the common (a) subunit of the glycoprotein hormone bovine lutropin has been identified as that between half-cystines 11 and 35; a second bond between residues 14 and 36 has also been established. The 11,35-bis(S-carboxymethyl) and bis(S-carbamoylmethyl) derivatives of the a: subunit have been prepared; both recombine with unmodified /z? subunit. The resultin...

Studies on the intracerebral toxicity of ammonia.

Interference with cerebral energy metabolism due to excess ammonia has been postulated as a cause of hepatic encephalopathy. Furthermore, consideration of the neurologic basis of such features of hepatic encephalopathy as asterixis, decerebrate rigidity, hyperpnea, and coma suggests a malfunction of structures in the base of the brain and their cortical connections. The three major sources of i...